Chemotherapy Biotherapy Certification ONS Practice Testq

Which drugs are administered using a continuous dosing method?

1. Vinca plant alkaloids

2. Antitumor antibiotics

3. Alkylating agents

4. Antimetabolites

The correct answer is: Antitumor antibiotics

The correct answer reflects the unique administration characteristics of antitumor antibiotics. These drugs, such as doxorubicin and bleomycin, have pharmacokinetic profiles that can support continuous dosing methods. This is often required to maintain effective therapeutic levels for prolonged periods, allowing for sustained activity against cancer cells. Continuous infusion can also help mitigate some of the side effects associated with high peak concentrations seen with bolus dosing. In contrast, vinca plant alkaloids, alkylating agents, and antimetabolites typically have different administration protocols, often favoring intermittent dosing rather than continuous infusion. Vinca plant alkaloids like vincristine are usually given as single doses due to their toxicity profiles. Alkylating agents are often administered in cycles to manage their toxicity and allow for recovery periods. Antimetabolites, such as methotrexate, are often given as infusions but more commonly in intermittent doses rather than continuously. Therefore, antitumor antibiotics are distinct in their compatibility with continuous dosing.