Chemotherapy Biotherapy Certification ONS Practice Testq

What is an important aspect of the pharmacodynamics of cyclophosphamide?

1. It is a hormonal therapy

2. It acts as a mitotic inhibitor

3. It creates cytotoxic effects through DNA cross-linking

4. It improves energy metabolism in cancer cells

The correct answer is: It creates cytotoxic effects through DNA cross-linking

Cyclophosphamide is classified as an alkylating agent, and its pharmacodynamics primarily involve the creation of cytotoxic effects through DNA cross-linking. This mechanism occurs when the drug attaches alkyl groups to the DNA molecule, leading to cross-linking of DNA strands. This process prevents the DNA from unwinding and separating, which is essential for DNA replication and transcription. As a result, this disruption can induce cell cycle arrest and ultimately lead to apoptosis or programmed cell death, particularly in rapidly dividing cancer cells. Understanding this action is crucial for recognizing how cyclophosphamide exerts its therapeutic effects in the management of various cancers. Its ability to damage the DNA of cancer cells directly contributes to its effectiveness in chemotherapy regimens.