Chemotherapy Biotherapy Certification ONS Practice Testq

What is a defining feature of cell cycle non-specific drugs?

1. They are effective only during the G2 phase

2. They act on dividing and resting cells

3. They can only be administered intravenously

4. They do not cause hair loss

The correct answer is: They act on dividing and resting cells

The defining feature of cell cycle non-specific drugs is that they have the ability to act on both dividing and resting cells. This characteristic sets them apart from cell cycle-specific agents, which are effective only during particular phases of the cell cycle, such as the G1, S, or G2 phases. Non-specific drugs can target cancer cells regardless of whether they are actively dividing or in a quiescent state, making them versatile in their application against a variety of tumors. This broad activity is particularly beneficial for treating tumors that may have a mix of actively dividing and resting cells. It provides an opportunity to affect a larger percentage of the tumor population, potentially leading to better treatment outcomes. This property is crucial in oncology, as solid tumors often have regions of cells in various phases of the cell cycle. The other options do not accurately describe the nature of cell cycle non-specific drugs. Their effectiveness is not limited to a specific phase, they can be administered via different routes beyond just intravenous, and hair loss, while a common side effect of many chemotherapy agents, is not a defining characteristic of non-specific drugs.