Chemotherapy Biotherapy Certification ONS Practice Testq

What is a common side effect of G-CSF administration?

1. Increased platelet count

2. Neutropenia

3. Bone pain

4. Anemia

The correct answer is: Bone pain

G-CSF, or Granulocyte Colony-Stimulating Factor, is commonly administered to stimulate the production of neutrophils in patients undergoing chemotherapy, as these patients frequently experience neutropenia. One of the most reported side effects of G-CSF administration is bone pain. This occurs because G-CSF works by stimulating the bone marrow to increase the production of neutrophils, which can lead to increased activity and pressure in the bone marrow spaces. Patients may experience discomfort or pain in the bones, particularly in the long bones and sternum, where active marrow is concentrated. The other options relate to conditions that may be influenced by G-CSF but are not typical side effects of the medication itself. Increased platelet count is not a direct effect of G-CSF; rather, the drug primarily affects neutrophil levels. Neutropenia would not be a side effect of G-CSF, since it is designed to mitigate that condition. Anemia is also not commonly associated with G-CSF, as the medication does not specifically target red blood cell production. Thus, bone pain stands out as a noteworthy and common side effect when administering G-CSF.