Chemotherapy Biotherapy Certification ONS Practice Testq

Non-hypoxic sensitizers are used in combination with radiation therapy for what purpose?

1. To decrease cell division

2. To increase the lethality of radiation effects

3. To enhance drug absorption

4. To promote tumor growth

The correct answer is: To increase the lethality of radiation effects

Non-hypoxic sensitizers are agents that enhance the effectiveness of radiation therapy in cancer treatment. The primary purpose of these sensitizers is to increase the lethality of radiation effects on tumor cells. Under normal circumstances, cancer cells may be relatively resistant to radiation, especially if they are in a hypoxic (low oxygen) environment. Non-hypoxic sensitizers work by making the cancer cells more susceptible to radiation damage. These sensitizers typically function by improving oxygenation in the tumor or by altering cellular pathways, which can enhance the impact of the radiation. By increasing the lethality of radiation effects, these agents help to ensure that more tumor cells are destroyed during treatment, ultimately leading to improved treatment efficacy. This is particularly important in the clinical setting, as it can make a significant difference in treatment outcomes for patients undergoing radiation therapy. In summary, the use of non-hypoxic sensitizers in combination with radiation therapy is fundamentally aimed at amplifying the destructive effects of radiation on cancerous cells, leading to better therapeutic results.